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Janice Lynn Manning was born January 10, 1950 in St. Louis a daughter to Clarence and Peggy (nee Driefus) Bowe. She had worked as a machine operator at A.T.I. and was very proud to have earned her real estate license She died at the Jefferson Regional Medical Center on May 27, 2012 at the age of 62.  She is survived by three daughters: Carrie (Gerald) Bouchard, Pacific, Amy (Tom) Hollmann, Malden, and Sarah Manning, Festus; eleven grandchildren: Christopher, Bryan, Kristian, Kamden, Gabriella, Amanda, Emily, Jody, Shane, Dustin, and Brady; three step-children Sandra Gillam, De Soto, Ron (Gail) Manning, De Soto, and Richard (Crystal) Manning, Park Hills; four sisters: Barbara Brosh, Festus, Jackie (Joe) Callahan, Byrnes Mill, Sandy (Gil) Perez, St. Petersburg, FL, and Terry Mesey, Alton. IL; one brother  Jim (Diane) Bowe, Arnold; and one sister-in-law: Betty Bowe, Hillsboro.  She is preceded in death by her parents, her husband: Robert Manning; one son: Brian Dorenkemp; one sister: Kathleen Bowe; one brother: Michael Bowe; and one grandchild: Jessica. Pastor Alan Amos will officiate the memorial service.